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报告题目：Programming Biological Membrane and Protocell Mimics with Sequence-Defined Janus Glycodendrimers
Fellow of the American Association for the Advancement of Science
Foreign Member of the Royal Swedish Academy of Engineering Sciences
Honorary Foreign Member of the Romanian Academy
Virgil Percec was born and educated in Romania (PhD in 1976). In 1981 he defected his native country and after short postdoctoral stays at the University of Freiburg in Germany (July-August 1981) and University of Akron, US (August 1981 to March 1982) he joined the Department of Macromolecular Science of Case Western Reserve University in Cleveland, US in March 1982 as an Assistant Professor. He was promoted to Associate Professor in 1984 and to Professor in 1986. In 1993 he was awarded the Leonard Case Jr. Chair at Case Western Reserve University and in 1999 he was invited to join the University of Pennsylvania in Philadelphia as P. Roy Vagelos Chair and Professor of Chemistry. He has been elected as Fellow of the American Association for the Advancement of Science, Honorary Foreign Member of the Romanian Academy, and Foreign Member of the Royal Swedish Academy of Engineering Sciences. His research reputation is also well recognized by a large number of awards including American Chemical Society Award in Polymer Chemistry (2004), National Science Foundation Research Award for Creativity in Research (1990, 1995, 2000, 2016), Alexander von Humboldt Research Award (1997), Staudinger-Durrer Medal (2005).
Our laboratory uses a materials genome approach to the discovery and prediction of programmed primary structures that are instructed to undergo intramolecular and intermolecular self-assembly, self-organization and the other sequences of events involved in the emergence of complex-homochiral biological functional systems . Materials genome uses the first principles employed in biology to design the tertiary structure responsible for a particular function. Since the mechanism of transfer of structural information in organic natural and synthetic compounds is not understood, theoretically the primary structures responsible for the creation of complex functional systems that are characterized by adaptation, self-control, self-organization, self-repair, etc. cannot be designed. This lecture will discuss the discovery of programmed primary structures that provide simple mimics of complex biological membranes and hybrid cells as well as their programmable glycan ligands [2,3]. Sequence-defined building blocks were used to generate multivalent membrane topologies that program glycan-ligands binding to sugar-binding proteins such as lectins and galectins at unexpected low levels of carbohydrate concentration when arranged in a suitable sequence [2,3]. Implications for biology and medicine will be discussed.